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Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed incretins (derived from incretion, a term used at that time to refer to a secretion that remains inside the body), hence the name incretin effect is still used today to describe the rise in insulin mediated by the action of these hormones

Systemic corticosteroids are well known to induce hyperglycaemia, primarily by increasing postprandial levels of glucose, insulin resistance and pancreatic -cell dysfunction 206 , that often necessitates the initiation of insulin therapy

The American Diabetes Association recommends comprehensive lifestyle counseling alongside pharmacotherapy