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(3) equipping the transmeningeal drug delivery device with a sealing mechanism to achieve site-specific effects

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Tufted astrocytes, characterised by accumulation of tau in proximal astrocytic processes, represent the histopathological hallmark of progressive supranuclear palsy, a rare neurodegenerative disorder with progressive impairment of balance, walking, eye movement, muscular rigidity, dysarthria, and dysphagia