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Similarly, anyone experiencing unexplained fatigue, weakness, neurological symptoms (such as numbness, tingling or problems with balance), or difficulty losing weight despite appropriate lifestyle measures should consult their GP

An alternative possibility is that reduced EAAT3 function leads to a maldistribution of glutamate, perhaps altering the synaptic-extrasynaptic glutamate ratio, and the ratio of NMDA activation, in particular brain circuits, and thereby leads to functional circuit abnormalities that fall short of neuronal death

Finally, 46 articles were examined entirely and included in the present study