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Most of the supplements that market this claim are based on small clinical trials, mostly in mice

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butyricum inhibits microbial translocation due to HIV infection by reducing harmful bacteria

Then in 2024, a systematic review and meta-analysis in the American Journal of Clinical Nutrition - covering 32 randomized controlled trials with 1,184 participants - found that chicory inulin-type fructan supplementation significantly reduced body weight compared to placebo