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In rodents, the enzyme long-chain acyl-CoA dehydrogenase (LCAD) can take over part of the VLCAD function, but in humans LCAD makes little contribution to lcFAO [6]

They play a key role in: Allergic reactions Wound healing Immune defense against pathogens Regulating inflammation When activated, mast cells release granules filled with bioactive substances, including: Histamine Tryptase Prostaglandins Leukotrienes Cytokines This process is called degranulation and in normal situations (e.g., in response to an insect sting or parasite), it's protective

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23 The main focus of this approach is to talk with patients who are initiating therapy about expected AEs, nonpharmacologic counseling, presence of any other GI conditions, and individualizing dose titrations