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Depression as a complex, systemic disease: Before we dive into the details of mitochondrial dysfunction in depression, Id like to point out that for many people, depression goes hand-in-hand with other chronic diseases, pointing to depression as being a systemic problem in the body

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Stable EndoC-H1 shRNA cell sublines were generated by infection of the parental EndoC-H1 line 40 with lentiviral particles expressing shRNA duplexes previously cloned into pLKO.3G (Addgene #14748)