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In vitro and preclinical studies indicate that cagrilintide retains high potency across amylin and calcitonin receptor subtypes and demonstrates additive pharmacodynamic effects when combined with GLP-1 agonists like semaglutide (DAscanio et al

Mechanism of action Cagrilintide is modified amylin: natural 37 amino acid sequence + conjugated C20-fatty acid via linker (like semaglutide) plasma albumin binding half-life extension from 12 min to ~7 days weekly dosing

doi: 10.1016/j.abb.2021.108926 169 YanSHuiYLiJXuXLiQWeiH

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