By focusing on smaller meals, monitoring fat intake, and starting with a gradual dose, you can successfully manage your weight and improve your metabolic health
Figure 1 Discussion In the presented case of a newly diagnosed patient with type 2 diabetes, euDKA occurred at the very early onset after initiation of combined therapy with GLP-1RA and SGLT2i, in the absence of infection or other precipitating factors (such as alcohol overdose, pancreatitis, pregnancy), and proved refractory to standard therapy with insulin, glucose, and fluid resuscitation
Wegovy is contraindicated during pregnancy, and for all semaglutide products, discontinuation is recommended at least 2 months before a planned pregnancy due to the long half-life of the medication
These findings are mostly applicable to individuals on metformin-based background therapy, while further trial data are required to determine whether the salutary metabolic effects of tirzepatide translate to long-term cardiovascular benefits