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Specifically, the putative G q -mediated mechanism is thought to involve PKC-mediated activation of an inward depolarising current carried by TRPM4/5 channels ( 2+ increases ( Numerous reports show that GPCRs also induce distinct cellular responses via separate, non-G protein-dependent signalling cascades facilitated by the recruitment of -arrestins, which act as scaffolds to promote interaction with and activation of mitogen-activated protein kinases (MAPKs) such as extracellular regulated kinase 1/2 (ERK1/2)
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(736) amide in type 2 (noninsulin-dependent) diabetic patients
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