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doi: 10.1016/S2213-8587(19)30192-5 32 HusainMBirkenfeldALDonsmarkMDunganKEliaschewitzFGFrancoDRet al

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Third, it upregulates VEGFR2 and activates the VEGFR2-Akt-eNOS pathway, accelerating blood vessel formation and blood flow recovery in ischaemic tissue, a mechanism confirmed in endothelial cell culture and rat hind-limb ischaemia models by Hsieh 2017