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Some providers extend the time at lower doses if a patient experiences significant GI side effects, and that is perfectly reasonable

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The pathway of peptides from the nasal cavity to the brain regions involves their epithelial uptake through the lamina propria, and influx to CSF passing through the cribriform plate or through the olfactory/trigeminal pathway in the axonal transport pathway (Dhuria et al., 2010)

Additionally, in patients treated at our institution recurrences occurred at a mean of 3.5 years from initial surgery, with 2 recurrences occurring beyond 5 years postoperatively, indicating the necessity of long-term follow-up in order to capture the true rate of recurrence of this tumor