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There have been reports of pulmonary aspiration (when food or liquid from the stomach enters the lungs) in people taking GLP-1 medications, including Wegovy, while undergoing surgery requiring sedation, even when instructed to fast before the surgery

PI3K is activated by the GLP-1 receptor coupled G subunits which consequently activate mitogen-activated protein kinases (MAPK), initiating gene expression that controls cell growth, repair, and differentiation [33, 37]

In fact, decades of research show that people taking GLP-1 medications may be more prone to dehydration, especially when intake drops or side effects make it harder to eat and drink enough (2,3)

AhrnBSimonssonELarssonHLandin-OlssonMTorgeirssonHJanssonPAet al