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the annual risk is individual Risk and prevention of bleeding in anticoagulant therapy bleeding risk is increased by older age, renal insufficiency, liver disease, prior bleeding, anemia, thrombocytopenia, uncontrolled hypertension, labile INR, alcohol excess, and concomitant antiplatelet or NSAID therapy many bleeding events occur at therapeutic INR

One way to do that is through sublingual (under the tongue) or buccal (cheek pouch) administration of psilocin the compound that psilocybin becomes after conversion

Those are trial averages, and individual response varied considerably around them