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This pathway was created as a part of [ Mendiola et cl], pictured in fig 5
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In another study, six weeks of 1000 mg NR supplementation per day for CKD patients improved mitochondrial metabolism, yet no effects were observed in the physical endurance of skeletal muscle 315
Contrary to the two models of halogenation in NRP biosynthesis presented above where halogenation occurs either on free amino acids or en route peptide assembly, chlorination during the biosynthesis of the RiPP antibiotic NAI-107 occurs after all other modifications on the RiPP precursor peptide have been installed, and the post-translationally modified C-terminal core has been proteolytically removed from the unmodified N-terminal core peptide [1, 42]
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