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Scientific American notes that glycogen is stored with water, which explains why some early weight loss is water weight rather than fat loss. Cleveland Clinic explains that starting with too large of a calorie deficit can lead to side effects such as fatigue, nausea, dehydration, constipation, headaches, and irritability. These symptoms are signals that energy intake may not be matching the bodys current needs

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Abstract Aims/hypothesis Metformin lowers postprandial glycaemic excursions in individuals with type 2 diabetes by modulating gastrointestinal function, including the stimulation of glucagon-like peptide-1 (GLP-1)

This compromises its ability to fertilize an egg