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A cholinergic-adrenergic hypothesis of mania and depression

A reduction in the "burning" sensation is a common early marker in subject logs

Practical Application Polyphenol-rich foods: Pomegranates, cranberries, blueberries, green tea Prebiotic fibers: Garlic, onions, leeks, asparagus Omega-3 sources: Fatty fish, walnuts, flaxseeds, chia seeds Fermented foods: Yogurt, kefir, sauerkraut, kimchi Avoid excessive antibiotics: When possible, preserve gut bacteria diversity Limit artificial sweeteners: May negatively impact beneficial bacteria Regular exercise: Supports beneficial bacterial populations Adequate sleep: 7-9 hours supports microbiome balance Strategy 4: Fatty Acid Signaling for L-Cell Activation The Science: L-cells express receptors that detect specific fatty acids in the intestinal lumen

An MRI-based exploratory analysis also indicated that cotadutide significantly reduced hepatic fat compared to placebo [84]