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In line, Prx6 knockout mice exhibit markedly reduced levels of GPX4 and other selenoproteins, with this decrease being particularly pronounced in the brain [177] , highlighting the critical role of this redoxin in selenium metabolism and providing a missing link in selenoprotein biology that explains how cells coordinate thiol and selenium metabolism to counteract lipid peroxidation

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Fishy odor: High doses of carnitine can lead to a fishy body odor due to the accumulation of a substance called trimethylamine in the body

However, its essential to note that these responses can be highly individualized, with some patients tolerating higher doses without significant reflux issues