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I asked ChatGPT to explain that better than myself so here are the mechanisms by which GLP1-RA does reduce hepatic glucose production: ChatGPT: GLP-1 receptor agonists (GLP1-RAs) reduce liver glucose production largely through indirect mechanisms rather than by acting directly on hepatocytes

Patients should contact their healthcare provider if they experience several days without a bowel movement despite using over-the-counter remedies, especially if accompanied by significant discomfort, as this may indicate more significant intestinal dysmotility requiring medical intervention

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Safety considerations specific to T1D Insulin requirements can fall quickly, reductions of around 30% are commonly discussed in practice