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Dietary modifications significantly reduce gastrointestinal symptoms: Eat smaller portions distributed throughout the day Choose lean proteins and complex carbohydrates Avoid high-fat, spicy, or heavily seasoned foods Stop eating when feeling satisfied, not full Separate liquid consumption from meals by 30 minutes Timing strategies help minimize discomfort

Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration

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