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Beyond thiopurines, the delayed gastric emptying induced by GLP-1RAs may theoretically affect other oral IBD medications

The molecule contains three intramolecular disulfide bonds (CysCys linkages), which constrain the peptide into a compact tertiary fold characteristic of the insulin superfamily

In addition, compound 2, an ago-positive allosteric modulator (ago-PAM), has been found to covalently bond to the intracellular side of transmembrane helix 6 (TM6) and allosterically induce insertion of the N-terminus of extracellular domain (ECD) into the orthosteric binding site of glucagon-like peptide-1 receptor (GLP-1R), thus triggering G s -biased activation 8