do you lose muscle mass on glp 1 Unlocking the Truth: Loss in Patients Using GLP-1 Medications – Trim Ozempic May Make Your Muscles

Berneis KK, Krauss RM

Semaglutide, better known by brand names such as Wegovy, is a glucagon-like peptide-1 (GLP-1) receptor agonist drug that has been approved by the U.S

10.1038/s41574-025-01114-y 2 AdelhorstK.HedegaardB

The TRIUMPH-4 trial showed that retatrutide at 12mg reduced: Systolic blood pressure: 14.0 mmHg reduction Non-HDL cholesterol: clinically meaningful improvement High-sensitivity C-reactive protein: significant reduction (a marker of systemic inflammation) Triglycerides: substantial decrease Tirzepatide produces similar cardiovascular improvements, with well-documented reductions in blood pressure, triglycerides, and inflammatory markers across the SURMOUNT and SURPASS programs