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Salinas A, Merino PM, Giraudo F, Codner E

Eur J Pharmacol (2020) 887:173581

Purifying long peptides is difficult, plus these GLP-1 peptide drugs have been modified to include a fatty acid side chain, and lipids themselves can be very difficult to purify, because theyre very hydrophobic, and tend to stick to the [purification] column, says Levine