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J Clin Neurol 7(1):1018 Pathan N, Kharod MK, Nawab S, Di Scipio M, Par G, Chong M (2024) Genetic determinants of vascular dementia

6,7 The ability of GLP-1 and its agonists to cross the bloodbrain barrier 810 suggests its therapeutic potential for NDs

This suggests that excessive GHK-Cu (or other copper peptides) might theoretically push skin MMP-1 concentrations beyond levels supporting healthy collagen production into ranges associated with collagen fragmentation and breakdown seen in older skin with naturally elevated MMP-1

Tirzepatide: Another Relevant Comparison Tirzepatide (Mounjaro/Zepbound), a dual GIP/GLP-1 agonist approved by the FDA, provides another useful reference point