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Animal Model:Naturally aged male C57BL/6 mice (20-24 months old) [1] Dosage:5 mg/kg Administration:Intraperitoneal injection, every other day for three administrations Result:Increased serum testosterone levels

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Introduction Acute Kidney Injury (AKI) is referred as a transient decline of renal function, which confers the severe clinical syndrome associated with high mortality ( It is well-known that AKI can arise in various pathological conditions, such as drugs, toxicants, ischemia/reperfusion (I/R), obstruction, or sepsis, resulting in acute tubular necrosis ( Ferroptosis is a recently described form of programmed cell death caused by uncontrolled iron dependent lipid peroxidation that distinguishes it from traditional modalities of regulated cell death including apoptosis, necrosis, and autophagy ( 2+ to the ferric form (Fe 3+ ) that sequesters free iron ( Additionally, the accumulation of lipid ROS is triggered when the endogenous antioxidant status is compromised