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Additionally, rare deficiencies of glutathione cycle enzymes (gamma-glutamylcysteine ligase, glutathione synthetase, 5-oxoprolinase, and gamma-glutamyl transferase) have all been associated with neuropsychiatric and cognitive impairments, although detailed phenomenological characterization has not been reported

reported elevated AAV vector expression during inflammatory episodes, while synthetic promoters responsive to proinflammatory signals provide a promising platform for integrating CRISPR-Cas9 and other editing tools (184, 185)