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Ion detection was achieved in ESI mode using a source capillary voltage of 3.5 kV, source temperature of 110 C, desolvation temperature of 200 C, cone gas flow of 50 l h 1 (N 2 ), and desolvation gas flow of 700 l h 1 (N 2 )

Preclinical studies indicate that these drugs shift macrophage polarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype through HIF-1 downregulation and AMPK activation, enhancing tissue repair and reducing oxidative stress (95, 96)

The processing time normally takes about one week