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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Prez L.P., Gonzlez R.S., Lzaro E.B

Aging and kidney biology Likewise, Related ERR-agonist work has examined mitochondrial dysfunction, inflammation, fibrosis, and renal function in aging models

In DM, hyperglycemia-induced ROS production worsens beta-cell failure and insulin resistance through pathways such as the AGE-RAGE signaling, protein kinase C (PKC) activation, and the polyol pathway