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In a study that compared the effects of carbamazepine, venlafaxine, and pregabalin in 257 patients with clinically definite DPN, carbamazepine significantly decreased the VAS score (from 74.5 to 39.6, P =0.0001) and showed similar effects as venlafaxine and pregabalin in improving scores for sleep, mood, and work interference [51]

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These mechanisms make biological sense and support a renoprotective hypothesis

Simponi has been licensed for use in the UK in adults (over 18) who have moderate to severe ulcerative colitis and have not responded to other medications