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More specific aspects that remain poorly understood are, first, how current research on the gut microbiome and intestinal physiology, immunology and the gutbrain axis can advance our understanding of gut health, and second, how the development of a clear framework for gut health could inform research on interventions commonly targeted towards the gut in healthy populations, including diet, probiotics, prebiotics and other biotic substances

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injections of 100 nmol kg 1 MK-801 ( n = 7-8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) for 14 days