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Paneth cells undergo degranulation, luminal extrusion and apoptosis following exposure to IFN- (Allaire et al

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The tolerogenic mechanism is elegant: by presenting histone epitopes in a context that promotes regulatory rather than effector T cell responses, these peptides essentially re-educate the immune system to tolerate its own nuclear components

Subcutaneous injection of PR65 in iron-depleted hepcidin knockout mice blocks iron overload in the liver, reduces iron levels in the heart, and causes iron retention in the spleen and duodenum