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Interest in the relationship between UA and PD was sparked by an autopsy study in which postmortem UA levels in the substantia nigra and striatum were lower in patients with PD than in age-matched controls [87]

Mechanism of Action in Research Models GIP receptor activation is studied in the context of incretin signaling, glucose-responsive pathways, and insulin physiology areas relevant to type 2 diabetes research models

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7.6.1 Strategic research priorities Future research should prioritize expanding multi-omics approaches for comprehensive exposure assessment, investigating cumulative and mixture effects to refine risk predictions, validating transgenerational epigenetic inheritance in human cohorts, developing targeted interventions for mitigating EED-induced reproductive damage, and establishing international regulatory standards for exposure limits and safety assessment