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The two main pathophysiological mechanisms of HOMA-IR are insulin resistance and pancreatic cell dysfunction due to insulin resistance [ Oral glucose tolerance test The oral glucose tolerance test (OGTT) was employed to evaluate glucose tolerance in overnight fasted rats orally given glucose (2 g/kg) 2 weeks after treatment (G18)

Visible results, especially for skin, may take a few weeks to months, depending on individual body response and consistency

Using a human intestinal epithelial platform with functional L-cells, researchers can now directly stimulate the epithelium and measure endogenous GLP-1 and other incretin secretion in a physiologically relevant context enabling mechanistic interrogation of secretion biology upstream of receptors