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In men with PD, recurrent subclinical tunical injury is thought to activate inflammatory and profibrotic pathways that can promote plaque formation and disease evolution in susceptible individuals

The most recent review on intranasal chelation was published in 2021 by Farr and Xiong, summarizing a decade of preclinical and translational studies on intranasal DFO in neurodegenerative and cerebrovascular conditions (Kosyakov et al., 2021

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Hardwick RN, Fisher CD, Canet MJ, Lake AD, Cherrington NJ (2010) Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease