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Welcome to the Shah Laboratory Drug Discovery in Cancer and Alzheimer's Disease Using Chemical Biology Cdk5 promotes Oxidative Stress and Mitochondrial Dysfunction in Alzheimers Disease Oxidative stress and mitochondrial dysfunction are one of the earliest events in Alzheimers disease (AD)

Result: reduction of chronic low-grade inflammation in tissues

These signs often go hand in hand with underlying gut conditions that block proper cobalamin absorption

Published studies have examined the compound in cell-based and animal research models relating to mitochondrial function, cellular respiration and exercise-responsive transcription