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Leptin act in the hypothalamus, where leptin inhibits neuropeptide Y (NPY) neurons and causes anorexia (Elmquist et al., 1999)

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doi: 10.1038/s41531-018-0058-0 85 YangWHamiltonJLKopilCBeckJCTannerCMAlbinRLet al

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MK-677 also produced a significant increase in insulin-like growth factor-I concentration

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