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How it works: Microneedling creates controlled micro-injuries that trigger natural wound healing and collagen production

All mice were fed with an irradiated chow diet (#1035 for reproductive feeding and #1025 for maintenance feeding, Beijing HFK Bioscience Co., Ltd, Beijing, China), with free access to drinking water

PMID: 2555512 PMC1572913 Pigmentation Pathway (MC1R, Preclinical) Eumelanin upregulation via cAMP / MITF / tyrosinase axis MC1R activation by melanocortin agonists is reported to raise intracellular cAMP, upregulate MITF, and increase tyrosinase-mediated eumelanin synthesis in epidermal melanocyte models