Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )
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The methods comprise the step of administering to the patient an amount of one or more hepatocyte growth factor mimics sufficient to reverse, ameliorate or slow progression of the at least one symptom
However, these drugs are limited: They slow but do not reverse fibrosis, they are poorly tolerated, and it remains to be established whether they are translatable to other fibrotic inflammatory disorders, highlighting the clinical unmet need for alternative targeted anti-fibrotic strategies