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NICE Technology Appraisals are mandated for NHS funding, and NHS organisations must normally fund treatments recommended by NICE within three months of guidance publication

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Costeffectiveness of prophylactic emicizumab versus prophylactic recombinant factor VIII in patients with moderate or mild hemophilia A without inhibitors in the United States

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Synthetic Cyanocobalamin for Reliable Supplementation The active ingredient, cyanocobalamin, is a laboratory-produced form of vitamin B12 that works in the body the same way as naturally occurring vitamin B12 found in fish, seafood, dairy products, and egg yolk

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The pooled HR from seven RCTs was 0.79 [95% CI 0.750.83], with low heterogeneity ( I =14%, p=0.32) showing consistent benefits across trials

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