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Dehydration is a known risk factor that can complicate blood pressure management on tirzepatide, since the medication reduces your appetite for food and sometimes for fluids

10.1016/j.toxicon.2017.10.016 10 ChristensenL.VivekanandhanS.MisraM.Kumar MohantyA

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A pragmatic response to this situation might be to suggest that for women who are on the pill and very keen to avoid pregnancy, that while they are experiencing active weight loss on GLP-1 [receptor agonists], they might consider themselves to be at higher risk of pregnancy and use additional methods, such as barrier contraception, until their weight stabilises, after which it seems likely that contraceptive efficacy would return towards normal. Hammarberg agreed