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Given that humans are unable to produce vitamin B12 (our gut bacteria produce very little during fermentation), vitamin B12 is considered an essential nutrient we need to obtain from our dietary intake

TB-500 (thymosin beta-4 fragment) has a longer serum half-life than BPC-157 in rodent models consistent with the convention of weekly TB-500 dosing vs daily BPC-157 dosing in standard research protocols

For TB-500, the status is similar (Investigational New Drug in the US) with very limited human data

Essential fatty acids are nutrients that our bodies need to maintain baseline health, but cant make enough on their own