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Impact of semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study
Therefore, it is not clear whether GLP-1 RA directly improves mitochondrial function, reduces ER stress, and reduces neuroinflammation, or indirectly improves these mechanisms by lowering blood glucose and improving IR
There is also a pharmacologic layer worth naming plainly
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Liraglutide was also shown to mitigate fibrosis in mice through the downregulation of NF-kB signaling and the decrease in levels of TGF-1, a key regulator of fibrosis in cancer-related lymphedema (Gou et al., 2014
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