Average weight loss was ( 7.8 pounds (3.55 kg) for a 3.75/23 mg (phentermine/topiramate) dose 16 pounds (7.27 kg) for a 7.5/46 mg dose 18 pounds (8.25 kg) for a 15/92 mg dose In users of phentermine-topiramate, weight loss translated to a significant decrease in waist circumference as well as improved insulin sensitivity, improved blood sugar management, and reduction in blood pressure ( May be helpful for certain eating disorders The combination of phentermine and topiramate may help reduce binge eating in people with BED and bulimia nervosa
GLP-1 medications like Ozempic (semaglutide), Mounjaro (tirzepatide) and even newer ones like retatrutide are changing the weight-loss landscape fast
Additional Benefits: Reduced craving for food, decreased addictive behaviors, a significant reduction in major cardiac events (27% reduction in fatal heart attacks), 7% reduction in stroke, decreased occurrence of obesity-related cancers, improved fertility in both men and women, reduced heart failure rates, and increased survival in heart failure patients
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism
