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Given the impact of MTHFR polymorphisms on methylfolate production, nuclear methylation, and the production of monoamines, there has been considerable research examining the association between MTHFR genetic variations and psychiatric disease states including unipolar depression, bipolar depression, schizophrenia, and more

10.1016/B978-0-12-405933-7.00002-0 120

Zhang WW, Shen PS, Descoteaux S, and Samuelson J