Several proteolytic pathways contribute to this process, including the ubiquitin-proteasome system, lysosomal autophagy, caspase-mediated hydrolysis, and calcium-dependent calpain activation [50, 51]
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Additionally, increased MCP-1 levels are associated with heightened blood-brain barrier (BBB) permeability, further complicating disease pathology by allowing more inflammatory cells to infiltrate the CNS [26]