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However, since IL-6 can cross the blood-brain barrier [67], the significant IL-6 sera levels determined at the first visit of ALS patients might have been abrogated at the second visit due to infiltration of this protein per se in addition to extravasation of inflammatory cells into the CNS parenchyma

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The commenters recommended that HCPCS code be reassigned to APC 5723 (Level 3 Diagnostic Tests and Related Services) as that APC reflects the clinical value and cost of this service