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For athletes, supplementation usually focuses on: Energy metabolism Endurance Recovery Fat utilization during exercise Within longevity-focused routines, the conversation shifts more toward mitochondrial health, healthy aging, and cellular energy production over time

Standardized processes are required for clinical translation where manufacturing processes will be standardized

Natural products also demonstrate promise: the fungal-derived meroterpenoid granulathiazole A (GA) activates Nrf2/HO-1 signaling, inhibits ferroptosis via SLC7A11/GPX4/FSP1 upregulation and ACSL4 downregulation, and reduces -syn accumulation across cellular and zebrafish models (Li et al., 2024a)