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In this interplay, for translating growth hormone actions into IGF-1 production, the production of endogenous insulin that reaches the liver via the portal vein is an essential factor

In particular, further research is needed to assess the response in specific subgroups, such as patients with higher BMI, and to compare clinical features between patients with and without muscle cramps to validate these findings

Vandenbeuch A, Anderson CB, Parnes J, Enjyoji K, Robson SC, Finger TE, Kinnamon SC

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