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Of those reporting no SGLT2i use at baseline, increasing numbers of participants started SGLT2i during the trial, with a greater proportion starting SGLT2i in the placebo (approximately 10% at 18 months and approximately 20% at 36 months) than in the semaglutide group (approximately 5% at 18 months and approximately 10% at 36 months

The SmPC advises patients to seek immediate medical attention if experiencing persistent, severe abdominal pain, often radiating to the back, accompanied by nausea and vomiting

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In one of these studies, Daniel Woronow, MD, and colleagues from the FDA in Silver Spring, Maryland found that 36 patients taking semaglutide between 2005 and 2016 developed acute gallbladder disease, three of whom died