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Stage 4 is less clearly defined, although studies suggest that the abnormal proteolytic activity is associated with increased levels of intracellular calcium, as well as binding of hemichromes (arising from denaturation of hemoglobin) to band 3 molecules

Both require renal function monitoringmetformin is contraindicated below eGFR 30 mL/min/1.73m

There is no need to taper off semaglutide

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