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Eur J Pharm Sci (2019) 128:10311

As the surface characteristics are primarily responsible for the toxicity of the NPs, modification of surface chemistry and properties has been reported to be one of the most common devised strategies to mitigate NP toxicity (Figure 3) ( FIGURE 3 Surface coating is one of the most popular surface modification strategies to reduce the potential toxicity of NPs, which is reversible by non-covalent modification (Wang et al., 2011)

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These microscopic structures come with either one bilayer (unilamellar) or multiple concentric bilayers (multilamellar)